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LiMAx test
The LiMAx test (maximum liver function capacity) is a dynamic liver function test based on the metabolism of 13C-methacetin by the liver-specific cytochrome P450 1A2 system. The test can be carried out at bedside displaying actual liver function at the point of measurement (Point-of-care testing).
== Test principle ==
The LiMAx test is an innovative enzymatic liver function test. 13C-methacetin, a selective metabolite of the liver specific cytochrome P450 1A2 is administered intravenously. Via the bloodstream the drug is transported to the liver and immediately metabolized to paracetamol and ultimately to 13CO2 (Fig. 1), which is in turn transported via the bloodstream to the lung and exhaled.
Cytochrome P450 1A2 is evenly distributed over all the cells of a liver acinus,〔C. N. Palmer, P. J. Coates, S. E. Davies, et al. Localization of cytochrome P-450 gene expression in normal and diseased human liver by in situ hybridization of wax-embedded archival material. Hepatology 1992;16(3):682-7〕 and is in contrast to other members of the cytochrome P450 family exclusively expressed in the liver. Cytochrome P450 A2 is usually not inducible by clinically frequently used drugs making it ideal even in complex clinical situations.
The test substance 13C methacetin itself is considered as is non-toxic and very well tolerated in the used dosage.〔G. A. Starmer, S. McLean, J. Thomas. Analgesic potency and acute toxicity of substituted anilides and benzamides. Toxicology and applied pharmacology 1971;19(1):20-8〕 Similarly, 13C is a stable, naturally occurring and non-radioactive carbon isotope. For this reason, patients need to fast for at least three hours before measurement to remove potential interferences with carbon from the food.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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